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Top-down estimates have been carried out on the costs generated by COPD in Spain using statistical and epidemiological data. These studies reported figures of around 800 million annually in 1994 including both direct and indirect costs. In a micro-economic study performed in 1,510 patients with ambulatory COPD followed over one year (bottomup), the average annual cost per patient was 1,876. From this study the approximate direct annual cost generated by COPD in Spain may be calculated from the prevalence. In the IBERPOC population-based epidemiological study, the prevalence of COPD was estimated to be 9 in the 4069 regina del cielo rallegrati alleluia age group, of which only 22 were diagnosed and received treatment of some kind.

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